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Antiretroviral therapy in Malawi

Research from the London School of Hygiene & Tropical Medicine in the UK and the Karonga Prevention Study in Malawi suggests that deaths from AIDS in rural parts of Malawi were averted by the rapid scale-up of free antiretroviral therapy. There was no change in the mortality rates of adults older than 6o years.

The study was funded by the Wellcome Trust and the British Leprosy Relief Association.

The Lancet has the published findings.

Rethinking HIV prevention

Researchers writing this month in the US journal Science have questioned the evidence base for current interventions aimed at reducing rates of HIV/AIDs. They argue that “Substantial investment in condom promotion, HIV testing and vaccine research has had limited success in Africa. Instead male circumcision and reducing multiple sexual partners should become the cornerstone of prevention.”

Others argue that too much is being spent on HIV prevention compared with diseases which kill more people and donors should consider shifting funding priorities.

Read more here.

 

Malawi clinic at forefront of paediatric AIDS care

One of Africa’s first modern clinics specialising in the treatment of children living with HIV/AIDS opened in Malawi this week. Malawi Health Minister Marjorie Ngaunje said the new Baylor College of Medicine International Paediatric AIDS Initiative would spell hope for the estimated 83,000 Malawi children now living with HIV/AIDS. Read more here.

Also this week, Malawi’s National Aids Commission reported that statistics for HIV/AIDS prevalance in 2007 was 12% - down from 14% in previous years.

Malaria nets

Andrew Conte, a young Canadian aid worker, reflects on the challenges of distributing malaria prevention bed nets in Sierra Leone in 2006We are very grateful to Andrew for sharing his experience.

In 2006, I mediated the planning, marketing and distribution of one million bed nets in Sierra Leone. Funded by the World Bank and Global Fund, there were enough bed nets supplied to cover nearly 20% of the country`s population and were distributed at no cost to beneficiaries concurrently with a measles immunization campaign targeting children under 5 years.

Where we successful? Did malaria infections decrease because of increased bed net use?

It’s difficult to say.

Prevalence rates for malaria in Sierra Leone did not exist prior to the campaign, nor has any vital population health data on malaria in Sierra Leone been reported since.

Historically, donors conduct follow-up household surveys a few months after bed net distribution occurs - but this data is never made readily available. I had occasion to observe one survey from Niger that reported less than 20% of inventory (2 million bed nets) distributed being retained by households and used as intended.

With global malaria infection rates reported to range from 300 to 500 million annually - the uncertainty of these estimates measured by the W.H.O. is also never reported. And despite our advanced knowledge of the epidemiology of malaria, there is a cloud of apathetic ambiguity that has engulfed present day malaria control and disease management practices.

 

A young Sierra Leonean with a malaria net

According to a recent article in the Journal of the American Medical Association entitled Global Malaria Control in the 21st Century: A Historic but Fleeting Opportunity (co-authored by Dr. Richard Feachem, former Executive Director of the Global Fund ), one of the latest exemplary successful management practices in malaria control has been bed net distribution campaigns (funded by the Global Fund of course) because of their efficacy in increasing bed net ownership.

In an environment where humanitarian organizations distribute goods for free, what does bed net ownership mean exactly?

How and when was ownership measured from that instant the bed net was handed over to mother and child? - Where coincidentally, the camera was also poised for a donor’s photo opportunity and a self-predicated success story for the fora of international public health.

Does bed net ownership imply proper behaviour change for bed net use in Sub-Saharan Africa, or any usage at all for that matter?

One must remember - the demographics whom these campaigns are targeting reside in rural areas of developing countries with tropical climates where very little technology, infrastructure and educational outlets exist.

The learning and acclimatization that must occur in order for the introduction of bed net technology to have a lasting effect on preventing malaria infection, such as hanging, education, and behaviour change, extends far beyond the term “ownership” - especially when given to beneficiaries for free.

Yet the rhetoric used by UN and Development agencies is common place. They report their (public tax) dollars (donated from Western countries) spent on aid interventions, and units donated to countries on massive scale - purchased from (Western) private suppliers that operate in monopolized markets - all which predicate irrelevant disease outcomes for those children in Sub-Saharan Africa, who are often carried by their mothers to health centers because they are infected by malaria with symptoms undetected, prevention unknown.

It’s time to break this cycle of carelessness.

Update from Selkirk

Have a look on the Project photo page to see new photographs of staff and patients at Selkirk Medical Practice in the Scottish Borders. Of particular interest are pictures of the ‘Baby Massage Clinic’ for new mothers and babies run by Practice Health Visitor, Rois Henderson. 

The Practice is twinned with Chileka in Blantyre, Malawi. Dr John Gillies from Selkirk is currently teaching a family medicine course in Malawi and plans to visit Chileka.

Patients photographed have given their consent for picutres to be shown on the Project site.

Mobile phones for global health

Following on from the blog post about how mobile phone text messaging has been used to support drug de-toxification in Dundee, readers of the Malawi Clinics Blog may be interested to learn that the United Nations and Vodafone have joined together to release a report entitled Mobile Technology for Social Change : Trends in NGO Mobile Use. The Report examines eleven case stutdies in ‘mobile activism’ and includes some interesting health-related projects including:

- Mobile health data collection systems in Kenya and Zambia

Collecting and tracking essential health data on handheld devices, in countries where statistical information was previously gathered via paper and pencil, if recorded at all.

- Monitoring HIV/AIDS care in South Africa

Using mobile devices to collect health data and support HIV/AIDS patient monitoring in a country with the world’s highest HIV/AIDS infection rates, and where rural populations often otherwise go unassisted.

- Sexual health information for teenagers

Connecting young people in the US and UK to important information on sexual and reproductive health via anonymous text messaging, to empower young people to make informed sexual health decisions.

- Continuing medical education for remote healthcare workers in Uganda

Providing medical updates and access to vital information via mobile phones for doctors and nurses working in some of the most destitute regions, where continuing medical education services are lacking.

MRSA and overuse of antibiotics

What is MRSA?

MRSA stands for methicillin-resistant Straphylococus aureus but is shorthand for any strain of this common bacteria that is resistant to one or more conventional antibiotics. MRSA is not completely resistant to antibiotics but patients may require a much higher dose over a much longer period, or the use of an alternative antibiotic to which the bug has less resistance.

What are the symptoms?

MRSA infections can cause a broad range of symptoms depending on the part of the body that is infected. These may include surgical wounds, burns, catheter sites, eye, skin and blood. Infection often results in redness, swelling and tenderness at the site of infection. Sometimes, people may carry MRSA without having any symptoms.

What is the link with hospitals and clinics?

The reason that hospitals and clinics seem to be hotbeds for resistant MRSA is because so many different strains are being thrown together with so many doses of antibiotics, vastly accelerating this natural selection process.

Prevention

Rigorous cleaning with warm water and detergent between patients is the most effective means of removing spores from the contaminated environment and the hands of staff, say experts. One of the main reasons that bacteria evolce into “superbugs” is the overuse of antibiotics, both in human and veterinary medicine. Until recently, patients visiting their doctor in Scotland with a viral infection might demand, and be given, an antibiotic prescription - despite the fact that antibiotics have no effect on this and may even strengthen the communities of bacteria in their bodies. Doctors have now been told to cut antibiotic prescribing.

Learning from Africa

Does the Malawian reliance on nursing staff for the treatment of most patients and the emphasis at clinics on professional hierachy and traditional nursing ‘matrons’ to manage wards offer lessons in the importance of hygiene and attention to detail for Scotland? Will the reality of a shortfall in the ready availability antibiotics and other medicines in Malawi lessen the effects of so-called superbugs? Share your thoughts on the blog.

Malawi nursing students demonstrate their starched white uniforms

Further sources of information on the web

The dangers of MRSA and Clostridium difficile

(Guardian Newspaper)

video clip with Q+A

(YouTube)

Health-care workers: source, vector, or victim of MRSA?

(The Lancet)

Infection control in paediatrics

(The Lancet)

Outreach - finding low-key solutions

Practice nurse Amiko Hippisley remembers working with limited resources in a rural setting near to Dedza in Malawi last summer:

“When we were working in Kaphuka Clinic (rural hospital) last July, some of the doctors did an outreach clinic about 5 kms away (for patients who can’t walk the distance to the clinic).  They did consultations, diagnosing & prescribing of medications all morning.  It was only on the return to the clinic that it was realised that the SP malaria tablets had been decanted by one of the staff into an old antibiotic container, and so all the patients who’d been prescribed antibiotics that morning had actually been given malaria treatment instead.  The clinic staff were quickly advised about not decanting medications into different containers, and if necessary to do this, to label the containers very clearly!  (Better this way round than the other as a lot of patients have malaria anyway.)

There is such a shortage of tablet containers and when we helped out in the pharmacy, we had to wrap up bundles of 5 malaria tablets into torn up bits of scrap paper.”

Prevention - travel advice at Scottish GP practices

The Practice Nurse at Stockbridge Blue Practice in Edinburgh, Scotland, (twinned with Ndirande in Blantyre, Malawi) regularly gives malaria prevention advice to patients travelling to malaria high-risk countries. Twinning Project team member, Jemma, consulted Amiko Hippisley before visiting Malawi in November. In this post, Amiko reviews routine procedure.

“Regarding our antimalarial advice we give to patients, I’ve learned as I’ve gone along but also use the Travax Travel health web-site for professionals (www.travax.scot.nhs.uk), which is done by SCIEH, based in Glasgow and updated daily (you need an ID & password).  Their sister travel web-site for the public is www.fitfortravel.scot.nhs.uk, which I give out to patients.  They are easy to use, with an A-Z index, so you click on the country and then click on ‘malaria map’ which gives a key guide, as antimalarial prophylaxis can vary within a country, depending on which region.  www.malariahotspots.co.uk is also a very useful and easy to use web-site for the public & health professionals.

Our patients fill out a travel form prior to their appointment and they get a single, double or triple appointment, depending on how many vaccines they need and how many countries they’re visiting for antimalarial advice and prescription.  The PN goes through the patient’s notes and computer records to see what vaccines they’re up-to-date with and which ones or boosters they need, prior to seeing the patient. I have Travax up on the screen during the consultation, as it’s better for the patient to visualise the country & malarious areas for their travels.

If they only need OTC (over the counter) tablets - chloroquine (daily) and/or proguanil (weekly), they are advised to buy them from the chemist.  They don’t need to remember the name/s, as the pharmacist will know what tablets are required.  I advise that proguanil can cause some patients to feel a bit nauseous but that’s better than contracting malaria. If they need a private prescription, which we charge £14.00 for (prescription & admin charge), we write them out for the patient but the GP signs it.  They are advised of the ‘double charge’, as the patient then needs to buy the tablets from the chemist also.

The OTC tablets are not effective in areas where the private tablets are required but the private tablets will also work in the areas where OTC tablets are needed.  This is due to the malaria resistance in the mosquitos in the milder areas.

The 3 choices of private tablets are:-

1. Malarone (atovaquone/proguanil), which is the most favoured because it has the least side-effects and is needed for a much shorter time.  It is a daily tablet, that is taken from 1-2 days before entry in to the malarious area, daily whilst there & then for a week after leaving the area.  They are the most expensive option.  Cost ~£1.60 per tablet.  It is the newest tablet to the market but has been out many years now.  Licensed for 36 days but can be prescribed for up to 6 months, if required.

2. Doxycycline 100 mg tablet.  Also daily but taken from about a week before, during and for a month after.  The benefit is that it is a broad spectrum antibiotic but has the side-effect of interfering with the pill and also causes skin photosensitivity.  High SPF is advised.  It can aalso cause oesophagitis/gastritis in some cases, so needs to be taken with a good amount of food or after meals!  Prices for this one vary a lot from chemist to chemist, so it’s worth shopping around!  Licensed for 3 months but can be prescribed for much longer.

3. Mefloquine/Lariam.  This costs about the same as malarone but is a weekly tablet, so works out a lot cheaper.  It potentially has the worst side-effects (neuro-psychiatric) and there’s a lot of scare-mongering about it but it only affects about 15% of people.  Can be prescribed long-term.

When prescribing these, we need to take in to account things like allergy to certain components of the tablets, epilepsy, contraception use, pregnancy, mental history, other medical conditions, etc. We always have to be on our toes so as not to make a mistake.

Prevention - NGO advocacy

US based charity ‘Africa Fighting Malaria‘ (AFM) has created an interactive map of Africa to indicate which countries are conducting ‘Indoor Residual Spraying’ (IRS) along with the main funders.

Project Director, Richard Tren, commented that: “World Malaria Day 2008 focuses on malaria across borders – and some of the best cross-border malaria control programs rely heavily on IRS.”

The AFM website also has some interesting sources of further information for those keen to learn more:

- Lessons from other nations in malaria fight

- World Malaria Day - just another PR swat at malaria?

- Uganda: DDT sprayed in Oyam